ABSTRACT
Papillary serous carcinomas of testis are very rare, and only case reports have been reported in the literature. These neoplasms are characterised histologically by papillary fronds and numerous psammoma bodies and exhibit immunoreactivity for markers of ovarian serous carcinomas. These are very aggressive and are both chemo and radioresistant with surgery remained the main stay of management.
ABSTRACT
Introducción: Los cuerpos de psammoma son calcificaciones bien circunscritas. Están descritas en una serie de neoplasmas. Caso clínico: Paciente mujer de 37 años de edad, con obesidad leve es sometida a gastrectomía tubular por obesidad, posterior a la evaluación por el equipo multidisciplinario. La biopsia postoperatoria informa de la presencia de cuerpos de psammoma en la mucosa gástrica. Discusión: Este es el primer caso publicado de cuerpos de psammoma en la mucosa gástrica tras manga gástrica. La paciente constituye un desafío en su seguimiento para detectar alteraciones en la mucosa gástrica.
Background: Psammoma bodies are a well circumscribed calcifications. They are described in some neplasms. Case report: Female 37 year-old patient with mild obesity, a sleeve gastrectomy was performed. The biopsy showed the presence of psammoma bodies in gastric mucosa. Discussion: This is the first case of psammoma bodies in gastric mucosa after a sleeve gastrectomy. This patient is a challenge to detect mucosa abnormalities in the future.
Subject(s)
Humans , Female , Adult , Calcinosis/pathology , Gastrectomy , Gastric Mucosa/pathology , Obesity/surgeryABSTRACT
Background and purpose:Gene fusions have been identiifed as recurrent oncogenic events in lung adenocarcinoma. Our purpose are to study the histologic features of anaplastic lymphoma kinase (ALK), c-ros oncogene 1 receptor tyrosine kinase (ROS1) andRETproto-oncogene fusion-positive lung adenocarcinomas and to evaluate the correlation between psammoma bodies and fusion-positive lung adenocarcinomas.Methods:In this study, we performed a comprehensive histologic analysis of 44 fusion-positive (including 15RET, 20ALK and 9ROS1) lung adenocarcinomas and 111 fusion-negative [including 20 epidermal growth factor receptor (EGFR), 20 Kirsten rat sarcoma viral oncogene (K-ras), 71 pan-negative] lung adenocarcinomas.Results:ALK,RET andROS1 fusion-positive lung adenocarcinomas were more prevalent in solid or acinar predominant adenocarcinoma. Multivariate analysis showed that tumors harboring a fusion gene had significantly higher prevalence of the presence of signet ring cells (P=0.000), micropapillary component (P=0.044), mucinous cribriform pattern (P=0.000) and extracellular mucin (P=0.010). The incidence of psammoma bodies was higher in the lung adenocarcinomas with a gene fusion than in tumors without gene fusions (P=0.000). Psammoma bodies were more likely to be found in tumors with any micropapillary component and/or mucinous cribriform pattern than in tumors lacking a micropapillary component and/or mucinous cribriform pattern (P=0.000).Conclusion:Our data showed that the presence of psammoma bodies, micropapillary component, mucinous cribriform pattern, extracellular mucin or signet ring cells may be either sensitive or speciifc to predict tumors harboring a fusion gene. These distinct morphologic features may be helpful in selecting cases for further accurate molecular testing.
ABSTRACT
Melanotic schwannoma is a rare form of pigmented neural tumor commonly arising from the posterior spinal nerves and ganglia. Two variants have been described, psammomatous and nonpsammomatous. 50% of psammomatous tumors are associated with Carney complex. The biologic behavior of the tumor is diffi cult to predict and slightly over 10% of the tumors follow malignant course. We present a case of psammomatous melanotic schwannoma as part of Carney complex in a 67-year-old male. Clinical examination revealed oral mucosal and abdominal skin pigmentation. Magnetic resonance imaging showed an intradural extramedullary lesion at D8-D12 level. Intraoperative squash smear study showed sheets of spindle cells with abundant intracytoplasmic melanin pigmentation and few psammoma bodies. Based on clinical, radiologic, and histopathological fi ndings with immunohistochemistry correlation a fi nal diagnosis of psammomatous melanotic schwannoma was rendered.